At least 400 people have broken through the border fence between Morocco and the enclave of Ceuta, which is part of Spain, reports the BBC.
The migrants, mainly from sub-Saharan Africa, stormed different points of the 6m-high (19ft) barbed-wire fence from 06:15 local time (07:15 GMT) on Friday.
It is the biggest single breach of the border in a decade, local media report.
Two border guards were injured in the surprise assault on the border, according to Spanish authorities.
Ceuta is a major crossing point for those seeking work or asylum in Europe.
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