US House Speaker John Boehner will resign from his leadership position and give up his seat at the end of October, the BBC reports.
Mr Boehner made the decision while praying on Friday morning - a day after hosting Pope Francis at Congress.
Fighting back tears, the 65-year-old said at a news conference that "turmoil" over his leadership would do lasting damage to the House.
Mr Boehner has been under pressure from the conservative wing of his party ever since he took the job in 2011.
He suggested a private moment with the pontiff was partly behind the decision.
"The Pope puts his arm around me and kinda pulls me to him, and says 'please pray for me'. Well, who am I to pray for the pope, but I did."
Mr Boehner becomes the first casualty in this new anti-establishment wave in the Republican Party.
The challenge of managing the day-to-day operations of the House of Representatives while satisfying an increasingly unruly - and growing - faction of hardcore conservative backbenchers has finally brought him down.
There once was a time when a speaker could bend the House of Representatives to his will by offering rewards and meting out punishment for transgressions.
Those days are long gone, as members of Congress now answer to outside constituencies and interests.
President Barack Hussein Obama said he was surprised by the news and had called Mr Boehner.
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